Re: Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. (article)

interesting.

thank you very much.

i wonder if dha is required, since epa can easily be converted to
dha...........

On May 17, 6:09 am, Pontus Granström <lepon...@gmail.com> wrote:
> Abstract
>
> Omega-3 fatty acids (i.e. docosahexaenoic acid; DHA), similar to exercise,
> improve cognitive function, promote neuroplasticity, and protect against
> neurological lesion. In this study, we investigated a possible synergistic
> action between DHA dietary supplementation and voluntary exercise on
> modulating synaptic plasticity and cognition. Rats received DHA dietary
> supplementation (1.25% DHA) with or without voluntary exercise for 12 days.
> We found that the DHA-enriched diet significantly increased spatial learning
> ability, and these effects were enhanced by exercise. The DHA-enriched diet
> increased levels of pro–brain-derived neurotrophic factor (BDNF) and mature
> BDNF, whereas the additional application of exercise boosted the levels of
> both. Furthermore, the levels of the activated forms of CREB and
> synapsin Iwere incremented by the
> DHA-enriched diet with greater elevation by the concurrent application of
> exercise. While the DHA diet reduced hippocampal oxidized protein levels, a
> combination of a DHA diet and exercise resulted in a greater reduction rate.
> The levels of activated forms of hippocampal Akt and CaMKII were increased
> by the DHA-enriched diet, and with even greater elevation by a combination
> of diet and exercise. Akt and CaMKII signaling are crucial step by which
> BDNF exerts its action on synaptic plasticity and learning and memory. These
> results indicate that the DHA diet enhanced the effects of exercise on
> cognition and BDNF-related synaptic plasticity, a capacity that may be used
> to promote mental health and reduce risk of neurological disorders.

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