Re: Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. (article)

Don't know, I'll have to investigate this, however it's nice that "our standing recommendation" running and fish oil seems to have solid scientific foundations.

On Tue, May 17, 2011 at 9:43 PM, whoisbambam <smathern@gmail.com> wrote:

interesting.

thank you very much.

i wonder if dha is required, since epa can easily be converted to
dha...........

On May 17, 6:09 am, Pontus Granström <lepon...@gmail.com> wrote:
> Abstract
>
> Omega-3 fatty acids (i.e. docosahexaenoic acid; DHA), similar to exercise,
> improve cognitive function, promote neuroplasticity, and protect against
> neurological lesion. In this study, we investigated a possible synergistic
> action between DHA dietary supplementation and voluntary exercise on
> modulating synaptic plasticity and cognition. Rats received DHA dietary
> supplementation (1.25% DHA) with or without voluntary exercise for 12 days.
> We found that the DHA-enriched diet significantly increased spatial learning
> ability, and these effects were enhanced by exercise. The DHA-enriched diet
> increased levels of pro–brain-derived neurotrophic factor (BDNF) and mature
> BDNF, whereas the additional application of exercise boosted the levels of
> both. Furthermore, the levels of the activated forms of CREB and

> synapsin Iwere incremented by the

> DHA-enriched diet with greater elevation by the concurrent application of
> exercise. While the DHA diet reduced hippocampal oxidized protein levels, a
> combination of a DHA diet and exercise resulted in a greater reduction rate.
> The levels of activated forms of hippocampal Akt and CaMKII were increased
> by the DHA-enriched diet, and with even greater elevation by a combination
> of diet and exercise. Akt and CaMKII signaling are crucial step by which
> BDNF exerts its action on synaptic plasticity and learning and memory. These
> results indicate that the DHA diet enhanced the effects of exercise on
> cognition and BDNF-related synaptic plasticity, a capacity that may be used
> to promote mental health and reduce risk of neurological disorders.

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